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Cross‐reaction and co‐sensitization among related and unrelated allergens in canine intradermal tests
Author(s) -
Buckley Laura,
Schmidt Vanessa,
McEwan Neil,
Nuttall Tim
Publication year - 2013
Publication title -
veterinary dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.744
H-Index - 60
eISSN - 1365-3164
pISSN - 0959-4493
DOI - 10.1111/vde.12044
Subject(s) - sensitization , medicine , immunology , cross reactions , antibody
Background Intradermal tests are used to identify allergens for avoidance and immunotherapy in atopic dogs. Hypothesis/Objectives To evaluate cross‐reaction or co‐sensitization among 53 intradermal test allergens. Animals Six hundred and fifty‐one client‐owned dogs with atopic dermatitis. Methods Intradermal tests were performed with 53 house dust/storage mite, epidermal, insect, tree, weed and grass pollen and mould allergens. P airwise comparisons were used to calculate the odds ratios ( OR s), 95% confidence intervals ( CI s) and statistical significance for the results of each allergen pair, with significance at P < 0.0006 (Holm–Bonferroni correction to reduce the false‐detection rate). Results Apart from cotton, cockroach, red clover, grain smut and P enicillium , the results for the allergens within each group were statistically associated [ OR s from 4.7 ( CI 2.5–8.9) to 1229.4 ( CI 166.5–1795.1); P = 0.0005 to P < 0.0001]. Excluding red clover and cotton, 94% of results between tree, weed and grass pollens were also statistically associated [ OR s from 8.3 ( CI 3.6–24.7) to 117 ( CI 29.1–341); P = 0.0005 to P < 0.0001]. In contrast, few allergens from unrelated groups were statistically associated [ OR s from 0.12 ( CI 0.03–1.1) to 27.7 ( CI 0.2–93); P = 1.0 to P < 0.0001]. The mean ( SD ) of the log e transformed OR s for the related and statistically associated allergens [5.3 (1.3)] was significantly greater than those for related but nonstatistically associated [1.7 (1.6)] or unrelated allergens [1.4 (1.4); P < 0.0001]. Conclusions and clinical importance This suggests that there is cross‐reaction or co‐sensitization between related allergens. This could have implications for allergen selection in testing and immunotherapy, but further studies are required to differentiate cross‐reaction from co‐sensitization.