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Age‐ and sex‐related changes in body weights and clinical pathology analytes in cynomolgus monkeys ( Macaca Fascicularis ) of Mauritius origin
Author(s) -
Li Xiantang,
Li Dingzhou,
Biddle Kathleen E.,
Portugal Susan S.,
Li Mark R.,
Santos Rosemary,
Burkhardt John E.,
Khan Nasir K.
Publication year - 2022
Publication title -
veterinary clinical pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 51
eISSN - 1939-165X
pISSN - 0275-6382
DOI - 10.1111/vcp.13094
Subject(s) - creatinine , physiology , medicine , age groups , triglyceride , body mass index , sexual dimorphism , cholesterol , pathology , endocrinology , biology , demography , sociology
Background Clinical pathology and body weight information for the cynomolgus monkey in the literature is primarily derived from a small number of animals with limited age ranges, varying geographic origins, and mixed genders. Objectives This study aimed to summarize the age‐ and sex‐related changes in clinical pathology analytes and body weights in cynomolgus monkeys of Mauritian origin. Methods Pre‐study age and body weight data were reviewed in 1819 animals, and pre‐study hematologic, coagulation, and serum biochemical analytes were reviewed in 1664 animals. Results Body weights were statistically higher ( P < 0.01) in males than females in all age groups (2–10 years). These measurements became prominent after 4 years of age and peaked at 7 to 8 years of age in both sexes. Sex‐related differences were noted in reticulocyte (RETIC) counts, creatinine, cholesterol, and triglyceride concentrations, and alkaline phosphatase (ALP) and gamma‐glutamyl transferase (GGT) activities. Age‐related differences were noted in RETIC and lymphocyte counts, creatinine, triglyceride, phosphorus, and globulin concentrations, and ALP and GGT activities. The youngest (2 to <3 year) age group had the fewest number of clinical pathologic analyte differences including ALP and GGT activity differences which occurred in all age groups from 2 to 10 years; they also had age‐related lower globulin concentrations. There were no age‐ or sex‐related differences in coagulation measurands. Conclusions Sexual dimorphism in body weight was apparent for all ages from 2 to 10 years of age. The only difference in clinical pathology analytes unique to the 2 to <3 years of age group were age‐related lower globulin levels.