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Comparison of creatine kinase in cerebrospinal fluid collected from the cerebellomedullary and lumbar cisterna in 10 dogs with neurologic disease
Author(s) -
Lampe Rachel,
Foss Kari D.,
Hague Devon W.,
Barger Anne M.
Publication year - 2020
Publication title -
veterinary clinical pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 51
eISSN - 1939-165X
pISSN - 0275-6382
DOI - 10.1111/vcp.12885
Subject(s) - cerebrospinal fluid , medicine , lumbar , cisterna magna , myelopathy , cisterna , lumbar puncture , central nervous system disease , pathology , spinal cord , radiology , biology , genetics , psychiatry , cell , golgi apparatus
Background Analysis of cerebrospinal fluid CK (CSF‐CK) might be useful as a prognostic indicator in dogs with neurologic disease. Previous studies have mostly analyzed CSF‐CK collected from the cerebellomedullary (CM) cisterna, but CSF collection sites could affect its levels. Objectives This is a pilot study aimed to evaluate differences in CSF‐CK concentrations when collected from the CM or lumbar cisterna in dogs presenting with neurologic disease. Methods Ten dogs presenting for neurologic disease underwent magnetic resonance imaging and CSF collection from both the CM and lumbar cisterna. Cerebrospinal fluid CK was analyzed within 30 minutes. Results Ten dogs were prospectively recruited. Overall, there was no statistically significant difference between CSF‐CK collected from the CM or lumbar cisterna ( P = .31). When evaluated by neurolocalization, CSF‐CK was different between sites in dogs with thoracolumbar myelopathy ( P = .024), but not in dogs with intracranial or cervical neurolocalization ( P = .93). All dogs with thoracolumbar myelopathy had equivocal or higher CK levels at the lumbar collection site compared with levels at the CM collection site. Conclusions Cerebrospinal fluid CK values differed depending on the CSF site collection, especially in dogs with thoracolumbar myelopathy. In dogs with thoracolumbar myelopathy, CSF‐CK was likely to be higher when CSF was taken from the lumbar cisterna compared with the CM cisterna. Collecting CSF from the thoracolumbar site could provide better prognostic information than if collected at the CM collection site.