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Lymphoma with Mott cell differentiation and validation of immunohistochemical lymphoid markers in an African pygmy hedgehog ( Atelerix albiventris )
Author(s) -
Cazzini Paola,
Richardson Jenna,
Smith Nicola,
Lodzinska Joanna,
Robinson Amy L.,
Philbey Adrian W.
Publication year - 2019
Publication title -
veterinary clinical pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 51
eISSN - 1939-165X
pISSN - 0275-6382
DOI - 10.1111/vcp.12816
Subject(s) - pathology , biology , population , hedgehog , lymphoma , mesenteric lymph nodes , stem cell marker , spleen , immunology , medicine , microbiology and biotechnology , stem cell , signal transduction , environmental health
A 2‐year‐old female intact African pygmy hedgehog was presented for diagnostic investigation of a 2‐month reduction in appetite, with weight loss and recent vomiting. Clinical examination revealed a large, firm mass originating from the left cranial abdomen. Ultrasound‐guided fine‐needle aspirates of the mass, liver, and mesenteric lymph nodes revealed a population of pleomorphic round cells, some of which contained variable numbers of round, clear vacuoles, consistent with a diagnosis of lymphoma with Mott cell differentiation. At postmortem examination, there was marked diffuse splenic enlargement, with infiltration by a soft tissue mass. There were multiple coalescing liver masses, kidney pallor, and mesenteric lymph node enlargements. On histologic examination, the spleen, lymph nodes, and masses in the liver were extensively infiltrated by proliferating lymphoid cells that had plasmacytoid and Mott cell differentiation. Cells with Mott cell morphology had an accumulation of periodic acid‐Schiff–positive material in cytoplasmic inclusions and were positive for cytoplasmic nucleic acids when stained with methyl green pyronin. In the population of neoplastic lymphoid cells, a majority of cells expressed the transcription factor Pax5, which drives B‐cell differentiation, and a minority expressed transcription factor IRF4/MUM‐1, which drives plasma cell differentiation, indicating B‐cell lymphoma with plasmacytoid differentiation.