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Canine reticulocyte hemoglobin content ( RET ‐H e ) in different types of iron‐deficient erythropoiesis
Author(s) -
Fuchs Jannika,
Moritz Andreas,
Grußendorf Esther,
Lechner Jörg,
Neuerer Felix,
Nickel Rafael,
Rieker Thomas,
Schwedes Claudia,
DeNicola Dennis B.,
Russell James,
Bauer Natali
Publication year - 2017
Publication title -
veterinary clinical pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 51
eISSN - 1939-165X
pISSN - 0275-6382
DOI - 10.1111/vcp.12499
Subject(s) - reticulocyte , microcytosis , medicine , erythropoiesis , hemoglobin , gastroenterology , anemia , ineffective erythropoiesis , iron deficiency , pathology , biology , biochemistry , messenger rna , gene
Background Reticulocyte hemoglobin content ( RET ‐H e ) is a diagnostic marker for iron deficiency ( ID ) in people and dogs. Objectives The aim of our study was to evaluate the clinical utility of RET ‐H e in the diagnosis of different causes of iron‐deficient erythropoiesis (IDE). Methods Canine CBC s were separated into 2 groups according to RET ‐H e values, < 20.9 pg or ≥ 20.9 pg. Erythrocyte and reticulocyte variables were compared between dogs with decreased and normal RET ‐H e values. Additional data for a subgroup of dogs were collected, and dogs with low RET ‐H e values were categorized as having ID, inflammatory disorders ( INFL ), portosystemic shunt ( PSS ), miscellaneous diseases ( MISC ), or combinations of these diseases ( ID + INFL , ID + PSS ). Hematologic variables were compared between dogs of the different disease groups. Results Overall, 10.3% (1084/10,553) of canine CBC s showed decreased RET ‐H e values. Significant differences between dogs with decreased and normal RET ‐H e values were found for all erythrocyte and reticulocyte variables. The majority (68.9%, 747/1084) of dogs with low RET ‐H e values was anemic; 28.9% (216/747) of those anemic dogs had microcytosis and hypochromasia. In the subgroup of dogs, 8.9% (205/2306) had low RET ‐H e values. According to their diagnosed diseases, anemic dogs (138/205) could be categorized as ID (17/138; 12.3%), INFL (16/138; 11.6%), PSS (30/138; 21.7%), ID + INFL (63/138; 45.7%), ID + PSS (8/138; 5.8%), and MISC (4/138; 2.9%). Distribution in nonanemic dogs (67/205) was similar, except for a lower number of dogs with PSS . Conclusions Low RET ‐H e values indicate IDE even in dogs with other CBC variables within the RI s.