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Correlation of serum cardiac troponin I and acute phase protein concentrations with clinical staging in dogs with degenerative mitral valve disease
Author(s) -
Polizopoulou Zoe S.,
Koutinas Christos K.,
Cerón José J.,
Tvarijonaviciute Asta,
MartínezSubiela Silvia,
Dasopoulou Anastasia,
York Malcolm J.,
Roman Ian F.,
Gandhi Mitul,
Patel Sonal,
O'Brien Peter J.
Publication year - 2015
Publication title -
veterinary clinical pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 51
eISSN - 1939-165X
pISSN - 0275-6382
DOI - 10.1111/vcp.12278
Subject(s) - troponin i , medicine , heart failure , cardiology , asymptomatic , c reactive protein , gastroenterology , troponin , haptoglobin , mitral valve , inflammation , myocardial infarction
Background Cardiac troponin I ( cTnI ) correlates with severity of myocardial injury. Nonspecific inflammation in congestive heart failure ( CHF ) could be assessed by C‐reactive protein ( CRP ), haptoglobin (Hp), and ceruloplasmin (Cp) measurements. Objectives The aim of the study was to determine whether serum cTnI , CRP , Hp, and Cp concentrations differ among various stages of mitral valve disease ( MVD ) in dogs. Materials and methods Dogs with MVD were allocated to 3 groups (I – asymptomatic; II – mild to moderate CHF ; III advanced CHF ) according to the scheme of the International Small Animal Cardiac Healthy Council ( ISACHC ). Concentrations of cTnI , CRP , Cp, and Hp were measured in all dogs upon admission, and cTnI and CRP were measured bimonthly during a 4‐month follow‐up period. Results In total 46 dogs with MVD were enrolled for the cross‐sectional part (21 Group I, 11 Group II , 14 Group III ), and 35 dogs were included in the longitudinal study. Initial mean Cp concentrations were similar among all groups. There was a statistically significant difference in Hp and CRP concentrations between group I ( n = 21, P = .019) and III ( n = 14, P < .001). There was a statistically significant decrease in CRP ( P = .033) and cTnI ( P = .009) concentrations over the longitudinal study (all groups). CRP concentrations were significantly higher in group I than III ( P = .004). During the 6‐month monitoring period of 35 dogs, there was a statistically significant positive correlation between cTnI and CRP ( P < .001). Conclusion Differences in CRP concentrations between clinical stages of MVD suggest a clinically and therapeutically relevant inflammatory component.