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Gamma delta T‐cell large granular lymphocyte lymphoma in a dog
Author(s) -
Ortiz Ana Liza,
Carvalho Sofia,
Leo Chiara,
Riondato Fulvio,
Archer Joy,
Cian Francesco
Publication year - 2015
Publication title -
veterinary clinical pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 51
eISSN - 1939-165X
pISSN - 0275-6382
DOI - 10.1111/vcp.12265
Subject(s) - procarbazine , vincristine , cd5 , medicine , lymphoma , pathology , t cell lymphoma , lymphocyte , labrador retriever , cd8 , chemotherapy , immunology , immune system , cyclophosphamide
A 2‐year and 6‐month‐old female neutered Labrador Retriever with Horner syndrome, megaesophagus, and a mediastinal mass was referred to the Queen Mother Hospital for Animals of the Royal Veterinary College. A large granular lymphocyte ( LGL ) lymphoma was diagnosed on cytology; flow cytometric analysis revealed a γδ T‐cell phenotype ( CD 3+, CD 5+, CD 45+, TCR γδ+, CD 4−, CD 8−, CD 34−, CD 21−). Chemotherapy was started with a combination of lomustine, vincristine, procarbazine, and prednisolone, followed by bleyomicin. Euthanasia was elected by the owners, due to progressive deterioration and lack of quality of life, 28 days after diagnosis. This is the first cytologic and immunophenotypic characterization of a canine γδ T‐cell lymphoma with LGL morphology and probably of mediastinal origin. The role of chemotherapy in delaying the disease progression remains unknown.