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Relationship between cobalamin‐dependent metabolites and both serum albumin and alpha 1 ‐proteinase inhibitor concentrations in hypocobalaminemic dogs of 7 different breeds
Author(s) -
Grützner Niels,
Suchodolski Jan S.,
Steiner Jörg M.
Publication year - 2014
Publication title -
veterinary clinical pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 51
eISSN - 1939-165X
pISSN - 0275-6382
DOI - 10.1111/vcp.12204
Subject(s) - cobalamin , albumin , serum albumin , medicine , beagle , endocrinology , chemistry , methylmalonic acid , breed , homocysteine , biology , vitamin b12 , zoology
Background Increased serum concentrations of homocysteine ( HCY ) and methylmalonic acid ( MMA ), the 2 main cobalamin‐dependent metabolites, as well as decreased serum albumin and canine alpha 1 ‐proteinase inhibitor (cα 1 ‐ PI ) concentrations have previously been described in hypocobalaminemic dogs with gastrointestinal disease. However, no studies have been conducted to evaluate potential relationships between these serum biomarkers. Objective The aim of this study was to evaluate the relationship between HCY and MMA , 2 cobalamin‐dependent metabolites, and both serum albumin and cα 1 ‐ PI concentrations in hypocobalaminemic dogs. Methods Serum samples from 285 dogs including 7 different breeds (Beagle, Boxer, Cocker Spaniel, German Shepherd, Labrador Retriever, Chinese Shar‐Pei, and Yorkshire Terrier) with hypocobalaminemia were used. Serum HCY , MMA , albumin, and cα 1 ‐ PI concentrations were determined. Results There was a significant correlation between serum HCY and albumin concentrations, as well as serum HCY and cα 1 ‐ PI concentrations (ρ = 0.62 and ρ = 0.37, respectively; P < .0001). No correlations were observed between serum MMA and albumin concentrations, or cα 1 ‐ PI concentrations (ρ = 0.01 and ρ = 0.08, respectively; P > .05). In addition, significant breed‐specific correlations were observed between serum MMA and albumin concentrations in German Shepherds, and serum HCY and MMA concentrations in Chinese Shar‐Peis with hypocobalaminemia. Conclusions This study shows a correlation between serum albumin and cα 1 ‐ PI and HCY concentrations, but not with serum MMA concentration in dogs with hypocobalaminemia. In addition, significant breed‐specific correlations were observed between serum MMA and albumin concentrations in German Shepherds, as well as serum HCY and MMA concentrations in Chinese Shar‐Peis, emphasizing the unique metabolic interactions in those dog breeds affected by hypocobalaminemia.