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Osseous metaplasia within a canine insulinoma
Author(s) -
Pieczarka Emily M.,
Russell Duncan S.,
Santangelo Kelly S.,
Aeffner Famke,
Burkhard Mary Jo
Publication year - 2014
Publication title -
veterinary clinical pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 51
eISSN - 1939-165X
pISSN - 0275-6382
DOI - 10.1111/vcp.12117
Subject(s) - insulinoma , medicine , synaptophysin , pathology , nodule (geology) , pancreas , differential diagnosis , hypoglycemia , carcinoma , cytology , radiology , immunohistochemistry , insulin , biology , paleontology
An 11‐year‐old male castrated mixed‐breed dog was presented for exercise intolerance, tetraparesis, and persistent hypoglycemia. Abdominal ultrasound examination revealed 2 nodules within the right limb of the pancreas. Cytology from one nodule was consistent with a carcinoma of neuroendocrine origin, with a primary differential diagnosis of insulinoma. Histologic evaluation and immunohistochemistry for synaptophysin and insulin confirmed the diagnosis of insulinoma. Additionally, there was a solitary nodule of mineralized compact bone composing approximately 60% of the mass. To the authors' knowledge, this is the first report of osseous metaplasia within an insulinoma (islet cell carcinoma).