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Breed‐specific biochemical reference intervals for the adult Dogue de Bordeaux
Author(s) -
Lavoué R.,
Geffré A.,
Braun J.P.,
Peeters D.,
Trumel C.
Publication year - 2013
Publication title -
veterinary clinical pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 51
eISSN - 1939-165X
pISSN - 0275-6382
DOI - 10.1111/vcp.12067
Subject(s) - breed , reference values , medicine , veterinary medicine , zoology , biology
Background Breed‐specific reference intervals are of increasing interest in veterinary medicine. The health monitoring of the Dogue de Bordeaux, a breed predisposed to familial juvenile glomerulonephropathy and hypothyroidism, would benefit from specific reference intervals. Objective The purpose of this study was to establish breed‐specific biochemical reference intervals for the Dogue de Bordeaux in accordance with the International Federation of Clinical Chemistry and Clinical and Laboratory Standards Institute guidelines. Methods One hundred and twenty Dogues de Bordeaux from France and Belgium were recruited. Complete urinalysis and chemistry panels, venous blood gas variables, total thyroxin and thyroid stimulating hormone, and fibrinogen and antithrombin were measured for each dog. Reference intervals were determined using the non‐parametric method. Confounding variables such as sex, age and color of facial mask were analyzed. Results Due to pre‐defined criteria for exclusion, 62 healthy dogs were finally selected for the reference intervals determination. Using the instrument manufacturer's generic canine RI for most analytes did not have a significant impact on potential clinical decisions, except for total proteins, ALT , AST , total cholesterol, lipase and total thyroxin, for which possible clinically relevant differences were noted. Conclusion Specific reference intervals for biochemical analytes in the Dogue de Bordeaux were determined under controlled pre‐analytical and analytical conditions, and according to international recommendations. The use of these breed‐specific reference intervals is recommended when using the specified analytic instruments, especially for the 6 analytes for which the reference intervals differed considerably from those provided by manufacturers.