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Markers of iron metabolism in retired racing Greyhounds with and without osteosarcoma
Author(s) -
Caro J. T.,
Marín L. M.,
Iazbik M. C.,
ZaldivarLópez S.,
Borghese H.,
Couto C. G.
Publication year - 2013
Publication title -
veterinary clinical pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 51
eISSN - 1939-165X
pISSN - 0275-6382
DOI - 10.1111/vcp.12066
Subject(s) - total iron binding capacity , serum iron , transferrin saturation , transferrin , haptoglobin , hematocrit , chemistry , iron deficiency , medicine , endocrinology , zoology , hemoglobin , anemia , biology
Background Greyhounds have well‐described clinicopathologic idiosyncrasies, including a high prevalence of osteosarcoma ( OSA ). Hematocrit, HGB, and HGB oxygen affinity are higher than in other dogs, while haptoglobin concentration is lower, so we hypothesized that Greyhounds have a different iron metabolism. To our knowledge, there are no reports on serum iron profiles in Greyhounds. Objectives To elucidate iron metabolism in Greyhounds, we wanted to compare serum iron concentration, total iron‐binding capacity ( TIBC ), and percent transferrin saturation (% SAT ) in healthy retired racing Greyhounds ( RRG s) with OSA ( RRG s – OSA ), and also with non‐Greyhounds ( NG s), without and with OSA ( NG s – OSA ). Methods Serum iron concentration and unsaturated iron‐binding capacity ( UIBC ) were measured by standard methods, and TIBC and % SAT were calculated in RRG s ( n = 25), RRG s – OSA ( n = 28), NG s ( n = 30), and NG s – OSA ( n = 32). Results TIBC was lower in RRG s than in NG s ( P < .0001), and in RRG s – OSA than in NG s – OSA ( P < .0001). NG s – OSA had lower TIBC than healthy NG s ( P = .003). Percent SAT was higher in RRG s than in NG s ( P < .0001) and in RRG s – OSA ( P = .008), and % SAT was also lower in NG s than in NG s – OSA ( P = .004). Percent SAT was also higher in RRG s – OSA than in NG s – OSA ( P = .001). Both RRG s – OSA ( P = .02) and NG s – OSA ( P < .0001) had lower serum iron concentrations than their healthy counterparts. Conclusion Lower TIBC and higher % SAT may constitute another Greyhound idiosyncrasy compared with other dogs. In this study, all dogs with OSA had higher serum iron concentrations and % SAT than healthy dogs.