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Best practices for veterinary toxicologic clinical pathology, with emphasis on the pharmaceutical and biotechnology industries
Author(s) -
Tomlinson Lindsay,
Boone Laura I.,
Ramaiah Lila,
Penraat Kelley A.,
Beust Barbara R.,
Ameri Mehrdad,
PoitoutBelissent Florence M.,
Weingand Kurt,
Workman Heather C.,
Aulbach Adam D.,
Meyer Dennis J.,
Brown Diane E.,
MacNeill Amy L.,
Bolliger Anne Provencher,
Bounous Denise I.
Publication year - 2013
Publication title -
veterinary clinical pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 51
eISSN - 1939-165X
pISSN - 0275-6382
DOI - 10.1111/vcp.12059
Subject(s) - clinical pathology , regulatory affairs , medicine , veterinary pathology , veterinary medicine , best practice , medical laboratory , pathology , medical physics , medical education , microbiology and biotechnology , political science , biology , law
The purpose of this paper by the Regulatory Affairs Committee ( RAC ) of the American Society for Veterinary Clinical Pathology ( ASVCP ) is to review the current regulatory guidances (eg, guidelines) and published recommendations for best practices in veterinary toxicologic clinical pathology, particularly in the pharmaceutical and biotechnology industries, and to utilize the combined experience of ASVCP RAC to provide updated recommendations. Discussion points include (1) instrumentation, validation, and sample collection, (2) routine laboratory variables, (3) cytologic laboratory variables, (4) data interpretation and reporting (including peer review, reference intervals and statistics), and (5) roles and responsibilities of clinical pathologists and laboratory personnel. Revision and improvement of current practices should be in alignment with evolving regulatory guidance documents, new technology, and expanding understanding and utility of clinical pathology. These recommendations provide a contemporary guide for the refinement of veterinary toxicologic clinical pathology best practices.