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Plasma 25‐hydroxyvitamin D and the inflammatory response in canine cancer
Author(s) -
Weidner Nicole,
Mutsaers Anthony J.,
Woods J. Paul,
Wood Geoff A.,
Bayle Julie,
Verbrugghe Adronie
Publication year - 2021
Publication title -
veterinary and comparative oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 34
eISSN - 1476-5829
pISSN - 1476-5810
DOI - 10.1111/vco.12667
Subject(s) - medicine , endocrinology , lymphoma , serum amyloid a , haptoglobin , cancer , inflammation , chemistry
Decreased circulating 25‐hydroxyvitamin D (25[OH]D) and increased inflammatory marker concentrations have been reported separately in canine cancer. Correlations between the two exist in humans, but little work has examined links in dogs. This study aimed to determine plasma 25(OH)D and inflammatory marker concentrations in healthy dogs and dogs with cancer and to assess correlations in each group. Newly diagnosed dogs with B‐cell lymphoma (B‐cell, n = 25), T‐cell lymphoma (T‐cell, n = 9), osteosarcoma (OSA, n = 21), and mast cell tumour (MCT, n = 26) presenting to a tertiary oncology centre, and healthy dogs (n = 25), were enrolled. Plasma samples were analysed for 25(OH)D, C‐reactive protein (CRP), haptoglobin (HP), serum amyloid A (SAA), alpha‐1‐acid glycoprotein (AAG), and 13 chemokines and cytokines. Dogs with B‐cell had decreased plasma 25(OH)D ( P = .03), and increased plasma CRP, AAG, HP, KC‐like and MCP‐1 concentrations ( P < =.001, .011, <.001, .013 and .009, respectively) compared with healthy dogs. Plasma CRP, HP and SAA concentrations were increased in dogs with OSA compared with healthy dogs ( P = .001, .010 and .027, respectively). No differences were noted in dogs with T‐cell and MCT. Negative correlations were observed between plasma 25(OH)D concentrations and: AAG concentrations in dogs with T‐cell ( R s = −0.817, P = .007); GM‐CSF concentrations (R s = −0.569, P = .007) in dogs with OSA; and IL‐7 concentrations (R s = −0.548, P = .010) in dogs with OSA. Decreased 25(OH)D concentrations and increased concentrations of multiple inflammatory markers were observed in B‐cell patients, supporting an association between 25(OH)D and inflammation. The cross‐sectional study design meant the timing of changes could not be determined. Prospective cohort studies are warranted.