Dysregulated expression of the key effectors of the mammalian target of rapamycin signalling pathway in cutaneous papillomas of dogs | Zendy

Sanz Ressel Berenice L. | Zendy; Massone Adriana R. | Zendy; Barbeito Claudio G. | Zendy

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Dysregulated expression of the key effectors of the mammalian target of rapamycin signalling pathway in cutaneous papillomas of dogs

Author(s) -

Sanz Ressel Berenice L.,

Massone Adriana R.,

Barbeito Claudio G.

Publication year - 2019

Publication title -

veterinary and comparative oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.864

H-Index - 34

eISSN - 1476-5829

pISSN - 1476-5810

DOI - 10.1111/vco.12516

Subject(s) - pi3k/akt/mtor pathway , hedgehog signaling pathway , protein kinase b , signalling pathways , immunohistochemistry , cancer research , effector , signalling , signal transduction , phosphatidylinositol , microbiology and biotechnology , biology , medicine , pathology

Cutaneous papillomas (CP) are one of the most common skin neoplasms in dogs. Different murine models have shown that persistent activation of the phosphatidylinositol 3‐kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway has a central role in the development and progression of CP. The purpose of this study were to evaluate the immunohistochemical expression pattern of two key molecules involved in the PI3K/Akt/mTOR signalling pathway, pAkt Ser473 , and pS6 Ser235/236 , on 36 canine specimens of CP using a tissue microarray. The results show that the PI3K/Akt/mTOR signalling pathway is persistently activated in CP of dogs, pointing to this pathway as a potential therapeutic target.

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