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Characteristics of extracellular cyclic AMP ‐dependent protein kinase as a biomarker of cancer in dogs
Author(s) -
Bhang D. H.,
Choi U. S.,
Kim B. G.,
Lee S.N.,
Lee S.,
Roh H.S.,
Chung W.J.,
Jeon K. O.,
Song W. J.,
Youn H.Y.,
Baek K.H.
Publication year - 2017
Publication title -
veterinary and comparative oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 34
eISSN - 1476-5829
pISSN - 1476-5810
DOI - 10.1111/vco.12304
Subject(s) - medicine , biomarker , cancer , breed , kinase , extracellular , protein kinase a , enzyme , gastroenterology , biology , biochemistry , genetics
Objective Early and proper diagnosis of cancer is the most critical factor for the survival and treatment of veterinary cancer patients. In this study, we evaluated extracellular cyclic AMP ‐dependent protein kinase A ( ECPKA ) level in serum as a useful cancer biomarker in dogs. Methods ECPKA levels were detected in sera from dogs with cancers ( n = 48), benign tumours ( n = 18), and non‐tumour diseases ( n = 102) as well as healthy control dogs ( n = 54) utilizing enzyme‐linked immunosorbent assay ( ELISA ). Results Sera from dogs bearing various types of cancer exhibited markedly increased levels of ECPKA by up to 7.1‐, 8.8‐, and 10.9‐fold compared with those from dogs harbouring benign tumours, dogs with non‐tumour diseases, and healthy control dogs, respectively ( P < .0001). In addition, serum ECPKA level did not show statistically significant correlation with gender, breed, or age of dogs or their non‐cancerous disease conditions. Conclusion Our data strongly propose that detection of serum ECPKA level is a potential and specific diagnostic tool for cancer in dogs.