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High COX ‐2 expression in canine mast cell tumours is associated with proliferation, angiogenesis and decreased overall survival
Author(s) -
Gregório H.,
Raposo T.,
Queiroga F. L.,
Pires I.,
Pena L.,
Prada J.
Publication year - 2017
Publication title -
veterinary and comparative oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 34
eISSN - 1476-5829
pISSN - 1476-5810
DOI - 10.1111/vco.12280
Subject(s) - angiogenesis , cd31 , carcinogenesis , medicine , immunohistochemistry , proportional hazards model , proliferation index , ki 67 , mast cell , cd68 , grading (engineering) , metastasis , cell growth , pathology , proliferation marker , oncology , cancer research , immunology , biology , cancer , ecology , genetics
COX ‐2 overexpression is associated with several hallmarks of carcinogenesis such as proliferation, angiogenesis, invasion and metastasis. Fifty cases of canine mast cell tumours ( MCT ) were retrospectively evaluated and submitted to immunohistochemistry for COX ‐2, CD31 , Ki‐67, MAC ‐387 and CD3 . Furthermore its relationship with clinicopathological variables and overall survival ( OS ) was analysed. COX ‐2 intensity ( P = 0.016), but not COX ‐2 extension nor score was associated with decreased OS and higher grades of malignancy according to Patnaik ( P = 0.002) and Kiupel ( P < 0.001) grading systems. Cox‐2 intensity was also associated with higher Ki‐67 scores ( P = 0.009), higher mitotic index ( P = 0.022) and higher microvascularization density ( P = 0.045). No association was observed for COX ‐2 intensity and CD3 ‐T lymphocyte ( P = 0.377) and macrophage infiltration ( P = 0.261) by MAC ‐387 immunollabelling, suggesting an active role of COX ‐2 in MCT oncogenesis mainly through proliferation and angiogenesis stimulation making it a potentially clinical relevant prognosis marker and therapeutic target.