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Transcriptome analysis of equine sarcoids
Author(s) -
Semik E.,
Gurgul A.,
Ząbek T.,
RopkaMolik K.,
Koch C.,
Mählmann K.,
BugnoPoniewierska M.
Publication year - 2017
Publication title -
veterinary and comparative oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 34
eISSN - 1476-5829
pISSN - 1476-5810
DOI - 10.1111/vco.12279
Subject(s) - transcriptome , carcinogenesis , microarray , gene , equidae , biology , microarray analysis techniques , gene expression , immune system , fold change , gene expression profiling , cancer research , computational biology , immunology , genetics , paleontology
Equine sarcoids are the most commonly detected skin tumours in Equidae . In the present research, a comparative transcriptomic analysis was performed which aimed at looking inside a tumour biology and identification of the expression profile as a potential source of cancer specific genes useful as biomarkers. We have used Horse Gene Expression Microarray data from matched equine sarcoids and tumour‐distant skin samples. In total, 901 significantly differentially expressed genes ( DEGs ) between lesional and healthy skin samples have been identified (fold change ≥ 2; P < 0.05). The large subset of DEGs , with decreased expression, was associated with a suppression of malignant transformation, whereas several overexpressed genes were involved in the processes associated with growth and progression of a tumour or immune system activity. Our results, as a first to date, showed comprehensive transcriptome analysis of skin tumour in horses and pinpointed significant pathways and genes related with oncogenesis processes.