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Gastric carcinoma in canines and humans, a review
Author(s) -
Hugen S.,
Thomas R. E.,
German A. J.,
Burgener I. A.,
Mandigers P. J. J.
Publication year - 2017
Publication title -
veterinary and comparative oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 34
eISSN - 1476-5829
pISSN - 1476-5810
DOI - 10.1111/vco.12249
Subject(s) - incidence (geometry) , stomach , medicine , carcinoma , gastric carcinoma , disease , curvatures of the stomach , breed , stage (stratigraphy) , population , gastroenterology , pathology , pedigree chart , cancer , oncology , biology , genetics , environmental health , paleontology , physics , gene , optics
Gastric carcinoma ( GC ) is the most common neoplasm in the stomach of dogs. Although incidence in the general population is reported to be low, breed‐specific GC has a high incidence. Median age at presentation ranges from 8 to approximately 10 years. The disease is mostly located in the lesser curvature and antropyloric region of the stomach. Unfortunately, diagnosis is usually made when the disease is at an advanced stage and, therefore, prognosis is poor. Due to similarities in clinical presentation, diagnosis, histology and prognosis, canine GC may serve as a valuable model for human GC . Extensive pedigrees of canine gastric carcinoma cases could reveal insights for human gastric carcinoma. Putative species differences include the role of Helicobacter in pathogenesis, the wide array of genetic data and screening available for humans, and treatment protocols that are available for human GC .