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Outcome in dogs with advanced (stage 3b) anal sac gland carcinoma treated with surgery or hypofractionated radiation therapy
Author(s) -
Meier V.,
Polton G.,
Cancedda S.,
Roos M.,
Laganga P.,
Emmerson T.,
Rohrer Bley C.
Publication year - 2017
Publication title -
veterinary and comparative oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 34
eISSN - 1476-5829
pISSN - 1476-5810
DOI - 10.1111/vco.12248
Subject(s) - medicine , surgery , stage (stratigraphy) , carcinoma , radiation therapy , paleontology , biology
Stage 3b anal sac gland carcinoma ( ASGC ) can be life‐threatening. A surgical approach is not always possible or may be declined. Dogs with stage 3b ASGC treated with surgery or conformal radiation therapy ( RT ) with 8 × 3.8 Gy (total dose 30.4 Gy, over 2.5 weeks) were retrospectively evaluated. Patient characteristics, median progression‐free interval ( PFI ) and median survival time ( MST ) were compared. Twenty‐eight dogs were included; 15 underwent surgery, 13 underwent RT . At the time of presentation, 21% showed life‐threatening obstipation and 25% showed hypercalcaemia. PFI and MST for surgery cases were 159 days (95% CI : 135–184 days) and 182 days (95% CI : 146–218 days), both significantly lower than for RT cases with 347 days (95% CI : 240–454 days) and 447 days (95% CI : 222–672 days), ( P = 0.01, P = 0.019). Surgery as well as RT led to a fast relief of symptoms. PFI and survival of surgical patients were significantly inferior to that of a comparable patient group treated with conformal hypofractionated RT .