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Nucleated erythrocytes in blood smears of dogs undergoing chemotherapy
Author(s) -
Moretti P.,
Giordano A.,
Stefanello D.,
Ferrari R.,
Castellano S.,
Paltrinieri S.
Publication year - 2017
Publication title -
veterinary and comparative oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 34
eISSN - 1476-5829
pISSN - 1476-5810
DOI - 10.1111/vco.12156
Subject(s) - vincristine , vinblastine , prednisone , chemotherapy , medicine , doxorubicin , carboplatin , cyclophosphamide , neutropenia , gastroenterology , cisplatin
Abstract The frequency of normoblastemia in dogs receiving chemotherapy is unknown. To provide this information, we calculated the percentage and number of nucleated erythrocytes ( nRBCs ) in blood of dogs treated for lymphoma ( n = 284), mast cell tumour ( n = 40) or carcinoma ( n = 46). Relative normoblastemia (>1 or >5%) and absolute normoblastemia (>0.1 or >0.4 × 10 3 µL −1 ) were found after administration of vincristine (49.3, 20.5, 42.5, 19.2%, respectively), carboplatin (37.0, 2.2, 34.8, 13.0%), cyclophosphamide (30.8, 7.7, 23.1, 7.7%), doxorubicin (25.0, 8.3, 21.7, 6.7%), vinblastine and prednisone (25.0; 5.0; 22.5; 7.5%). Absolute normoblastemia was very severe (>1.0 × 10 3 nRBC µL −1 ) after administration of vincristine (9.6%), doxorubicin (3.3%), vinblastine and prednisone (2.5%). Absolute normoblastemia negatively correlated with RBC counts ( P < 0.001) and positively ( P < 0.001) with reticulocyte and WBC counts, but correlation coefficients were low (−0.19, 0.37, 0.15). Vincristine, doxorubicin or vinblastine and prednisone may induce severe normoblastemia. This may increase WBC counts and mask neutropenia associated with chemotherapy.