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PCNA and grade in 13 canine oral squamous cell carcinomas: association with prognosis
Author(s) -
Mestrinho L. A.,
Faísca P.,
Peleteiro M. C.,
Niza M. M. R. E.
Publication year - 2017
Publication title -
veterinary and comparative oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 34
eISSN - 1476-5829
pISSN - 1476-5810
DOI - 10.1111/vco.12134
Subject(s) - proliferating cell nuclear antigen , medicine , surgical margin , basal cell , pathology , lymph node , metastasis , lymph node metastasis , antigen , immunohistochemistry , oncology , cancer , immunology
This study evaluated the prognosis factors of age, tumour size, anatomic location, histological grade and proliferating cell nuclear antigen ( PCNA ) expression in 13 dogs with oral squamous cell carcinoma ( OSCC ) with bone invasion and without signs of lymph node or distant metastasis. All animals were treated with radical excision performed with at least 1 cm margin, based on computed tomography images. In the 2‐year follow‐up, median disease‐free survival was 138 days for dogs with grade 3 tumours and was not reached for those with grade 2 tumours. Grade 3 tumours and PCNA labelling index ≥65% were related with a shorter disease‐free survival time and consequently poor prognosis ( p = 0.003 and p = 0.034, respectively). Mean PCNA labelling index was significantly higher in recurrent cases ( p = 0.011). Histological grade and PCNA expression may be important prognosis factors in canine OSCC .