PCNA  and grade in 13 canine oral squamous cell carcinomas: association with prognosis | Zendy

Mestrinho L. A. | Zendy; Faísca P. | Zendy; Peleteiro M. C. | Zendy; Niza M. M. R. E. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

PCNA and grade in 13 canine oral squamous cell carcinomas: association with prognosis

Author(s) -

Mestrinho L. A.,

Faísca P.,

Peleteiro M. C.,

Niza M. M. R. E.

Publication year - 2017

Publication title -

veterinary and comparative oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.864

H-Index - 34

eISSN - 1476-5829

pISSN - 1476-5810

DOI - 10.1111/vco.12134

Subject(s) - proliferating cell nuclear antigen , medicine , surgical margin , basal cell , pathology , lymph node , metastasis , lymph node metastasis , antigen , immunohistochemistry , oncology , cancer , immunology

This study evaluated the prognosis factors of age, tumour size, anatomic location, histological grade and proliferating cell nuclear antigen ( PCNA ) expression in 13 dogs with oral squamous cell carcinoma ( OSCC ) with bone invasion and without signs of lymph node or distant metastasis. All animals were treated with radical excision performed with at least 1 cm margin, based on computed tomography images. In the 2‐year follow‐up, median disease‐free survival was 138 days for dogs with grade 3 tumours and was not reached for those with grade 2 tumours. Grade 3 tumours and PCNA labelling index ≥65% were related with a shorter disease‐free survival time and consequently poor prognosis ( p = 0.003 and p = 0.034, respectively). Mean PCNA labelling index was significantly higher in recurrent cases ( p = 0.011). Histological grade and PCNA expression may be important prognosis factors in canine OSCC .

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research