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Splenic and hepatic ultrasound and cytology in canine lymphoma: effects of findings on stage migration and assessment of prognosis
Author(s) -
Nerschbach V.,
Eberle N.,
Joetzke A. E.,
Hoeinghaus R.,
Hungerbuehler S.,
Mischke R.,
Nolte I.,
Betz D.
Publication year - 2016
Publication title -
veterinary and comparative oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 34
eISSN - 1476-5829
pISSN - 1476-5810
DOI - 10.1111/vco.12127
Subject(s) - cytology , stage (stratigraphy) , medicine , canine lymphoma , lymphoma , spleen , ultrasound , chemotherapy , pathology , radiology , biology , paleontology
Stage migration is described in humans and dogs as a sequel of using more sensitive diagnostic methods. One hundred eighty‐six dogs with multicentric lymphoma were enrolled with results of conventional staging as well as ultrasonographic and cytological examination of liver and spleen being available. The addition of splenic respective hepatic ultrasound and cytology findings resulted in slightly lower number of dogs classified as having liver and spleen involvement. In dogs with multicentric lymphoma, addition of cytology led to a significant shift of individuals from stage IV to stage III . Findings of hepatic and splenic ultrasound and cytology exerted no significant influence on complete remission and survival durations in dogs with combination chemotherapy. Staging methodology in canine lymphoma should be redefined, considering that the prognostic significance of splenic and hepatic ultrasound and cytology warrants further investigation.