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A comparison of clinical, magnetic resonance imaging and pathological findings in dogs with gliomatosis cerebri, focusing on cases with minimal magnetic resonance imaging changes ‡
Author(s) -
Bentley R. T.,
Burcham G. N.,
Heng H. G.,
Levine J. M.,
Longshore R.,
CarreraJustiz S.,
Cameron S.,
Kopf K.,
Miller M. A.
Publication year - 2016
Publication title -
veterinary and comparative oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 34
eISSN - 1476-5829
pISSN - 1476-5810
DOI - 10.1111/vco.12106
Subject(s) - magnetic resonance imaging , pathology , pathological , lesion , differential diagnosis , medicine , central nervous system , glioma , immunohistochemistry , radiology , cancer research
The primary study objective was to determine whether clinical examination and magnetic resonance imaging ( MRI ) can underestimate canine gliomatosis cerebri ( GC ); we also investigated immunohistochemical features. Seven dogs with GC were studied; four recruited specifically because of minimal MRI changes. Neuroanatomic localization and the distribution of MRI , gross and sub‐gross lesions were compared with the actual histological distribution of neoplastic cells. In six cases, clinical examination predicted focal disease and MRI demonstrated a single lesion or appeared normal. Neoplastic cells infiltrated many regions deemed normal by clinical examination and MRI , and were Olig2‐positive and glial fibrillary acid protein‐negative. Four dogs had concurrent gliomas. GC is a differential diagnosis for dogs with focal neurological deficits and a normal MRI or a focal MRI lesion. Canine GC is probably mainly oligodendrocytic. Type II GC , a solid glioma accompanying diffuse central nervous system neoplastic infiltration, occurs in dogs as in people.