Premium
Prognostic value of baseline absolute lymphocyte concentration and neutrophil/lymphocyte ratio in dogs with newly diagnosed multi‐centric lymphoma
Author(s) -
Mutz M.,
Boudreaux B.,
Kearney M.,
Stroda K.,
Gaunt S.,
Shiomitsu K.
Publication year - 2015
Publication title -
veterinary and comparative oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 34
eISSN - 1476-5829
pISSN - 1476-5810
DOI - 10.1111/vco.12045
Subject(s) - canine lymphoma , lymphoma , medicine , lymphocyte , chop , immunophenotyping , neutrophil to lymphocyte ratio , absolute neutrophil count , multivariate analysis , chemotherapy , gastroenterology , oncology , immunology , flow cytometry , neutropenia
Canine multi‐centric B‐cell lymphoma shares similarities with diffuse large B‐cell (Non‐Hodgkin's) lymphoma ( NHL ) in people. In people with NHL , lymphopenia at diagnosis and first relapse and neutrophil/lymphocyte ratio (N:L) > 3.5 are negative prognostic factors for survival. The objective of this study was to determine if lymphocyte concentration at diagnosis and first relapse and N:L were prognostic for survival in dogs with newly diagnosed multi‐centric lymphoma. Medical records of 77 dogs with multi‐centric lymphoma treated with a CHOP ‐based chemotherapy protocol were retrospectively evaluated. Absolute lymphocyte concentration and N:L ratio at presentation of dogs pre‐treated with steroids was not significantly different from dogs who had not received steroids. On multivariate analysis, only immunophenotype remained significant for progression‐free survival ( PFS ), whereas no variables remained significant for ST . A prospective study of these haematologic variables is warranted to assess their true significance.