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Comparison of mitotic index and Ki67 index in the prognostication of canine cutaneous mast cell tumours
Author(s) -
Berlato D.,
Murphy S.,
Monti P.,
Stewart J.,
Newton J. R.,
Flindall A.,
Maglen G. A.
Publication year - 2015
Publication title -
veterinary and comparative oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 34
eISSN - 1476-5829
pISSN - 1476-5810
DOI - 10.1111/vco.12029
Subject(s) - mitotic index , medicine , mast cell , hazard ratio , proliferation index , index (typography) , oncology , mitosis , pathology , biology , immunohistochemistry , immunology , confidence interval , world wide web , computer science , microbiology and biotechnology
Proliferation markers are commonly used for prognostication of mast cell tumours. The aim of the study is to compare the relative abilities of Ki67 and mitotic index to predict survival in the same cohort of dogs with cutaneous MCTs . Histological grade, mitotic index and Ki67 index were performed in all samples and clinical information was obtained by a follow‐up questionnaire. Ninety‐five dogs were included in the study with a median follow‐up of 1145 days. Survival times varied significantly between categories of histological grade, mitotic index and Ki67 index. Multivariable analyses showed that the risk of dying due to MCT was similar in dogs with increased Ki67 index [hazard ratio, HR : 3.0 (95% CI 1.3–6.8)] or increased mitotic index [ HR : 2.7 (95% CI 1.1–6.5)]. In conclusion, both mitotic index and Ki67 index were able to independently differentiate MCTs with worse prognosis. This distinction is particularly meaningful in selecting intermediate grade MCTs that may benefit from more aggressive local or systemic treatment.