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Biological behaviour of canine mandibular osteosarcoma. A retrospective study of 50 cases (1999–2007)
Author(s) -
Coyle V. J.,
Rassnick K. M.,
Borst L. B.,
Rodriguez C. O.,
Northrup N. C.,
Fan T. M.,
Garrett L. D.
Publication year - 2015
Publication title -
veterinary and comparative oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 34
eISSN - 1476-5829
pISSN - 1476-5810
DOI - 10.1111/vco.12020
Subject(s) - medicine , osteosarcoma , retrospective cohort study , chemotherapy , univariate analysis , mitotic index , metastasis , multivariate analysis , adjuvant chemotherapy , surgery , oncology , gastroenterology , pathology , cancer , biology , breast cancer , microbiology and biotechnology , mitosis
The purpose of this retrospective study was to describe the biological behaviour of canine mandibular osteosarcoma ( OSA ) and to examine factors for their impact on metastasis‐free interval ( MFI ) and survival time ( ST ). Records from dogs treated with mandibulectomy for OSA (1999–2007) were reviewed. Archived tumour samples were evaluated for mitotic index ( MI ) and tumour grade. Fifty dogs were included, 21 received chemotherapy. Twenty‐nine dogs (58%) developed metastatic disease. The median MFI was 627 days, and median ST was 525 days. In univariate analysis MI > 40 was prognostic for decreased MFI and ST . Grade also influenced MFI and ST , with 5/21 (24%) dogs with grade II / III tumours metastasis‐free at one year versus 16/22 (72%) dogs with grade I tumours ( P = 0.002); and 5/21 (24%) dogs with grade II / III tumours alive versus 17/22 (77%) dogs with grade I tumours ( P = 0.001). In multivariate analysis, histological grade and adjuvant chemotherapy were prognostic for MFI and ST .