Open AccessOrganoid transplant approaches for the liver
Author(s) -
Reza Hasan Al,
Okabe Ryo,
Takebe Takanori
Publication year - 2021
Publication title -
transplant international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.998
H-Index - 82
eISSN - 1432-2277
pISSN - 0934-0874
DOI - 10.1111/tri.14128
Subject(s) - organoid , economic shortage , induced pluripotent stem cell , transplantation , liver transplantation , medicine , stem cell , progenitor cell , regenerative medicine , regeneration (biology) , cancer research , microbiology and biotechnology , biology , embryonic stem cell , linguistics , philosophy , biochemistry , government (linguistics) , gene
Summary Organoid technology is a state‐of‐the‐art cell culture tool that has revolutionized study of development, regeneration, and diseases. Human liver organoids (HLOs) are now derived from either adult stem/progenitors or pluripotent stem cells (PSCs), emulating cellular diversity and structural symphony akin to the human liver. With the rapid rise in decompensated liver disease conditions only treated by liver transplant therapy, HLOs represent an alternate source for transplantation to address the ongoing shortage of grafts. Although ongoing advancements in bioengineering technology have moved the organoid transplant approach to the next level, sustained survival of the transplanted tissue still eludes us toward functional organ replacement. Herein, we review the development of HLOs and discuss promises and challenges on organoid transplant approaches.