Open AccessRecovery of kidney function after AKI because of COVID‐19 in kidney transplant recipients
Author(s) -
Bajpai Divya,
Deb Satarupa,
Bose Sreyashi,
Gandhi Chintan,
Modi Tulsi,
Katyal Abhinav,
Saxeikhil,
Patil Ankita,
Thakare Sayali,
Pajai Atim E.,
Haridas Ashwathy,
Keskar Vaibhav S.,
Jawale Sunil Y.,
Sultan Amar G.,
Jamale Tukaram E.
Publication year - 2021
Publication title -
transplant international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.998
H-Index - 82
eISSN - 1432-2277
pISSN - 0934-0874
DOI - 10.1111/tri.13886
Subject(s) - medicine , acute kidney injury , proteinuria , renal function , thrombotic microangiopathy , orthostatic vital signs , nephrology , kidney disease , kidney transplantation , kidney , urology , disease , blood pressure
Summary Evidence on the evolution of graft function in kidney transplant recipients recovering from coronavirus disease‐2019 (COVID‐19) is lacking. This multicenter observational study evaluated the short‐term clinical outcomes in recipients with acute kidney injury (AKI) secondary to COVID‐19. Out of 452 recipients following up at five centers, 50 had AKI secondary to COVID‐19. 42 recipients with at least 3‐month follow‐up were included. Median follow‐up was 5.23 months [IQR 4.09–6.99]. Severe COVID‐19 was seen in 21 (50%), and 12 (28.6%) had KDIGO stage 3 AKI. Complete recovery of graft function at 3 months was seen in 17 (40.5%) patients. Worsening of proteinuria was seen in 15 (37.5%) patients, and 4 (9.5%) patients had new onset proteinuria. Graft failure was seen in 6 (14.3%) patients. Kidney biopsy revealed acute tubular injury (9/11 patients), thrombotic microangiopathy (2/11), acute cellular rejection (2/11), and chronic active antibody‐mediated rejection (3/11). Patients with incomplete recovery were likely to have lower eGFR and proteinuria at baseline, historical allograft rejection, higher admission SOFA score, orthostatic hypotension, and KDIGO stage 3 AKI. Baseline proteinuria and the presence of orthostatic hypotension independently predicted incomplete graft recovery. This shows that graft recovery may remain incomplete after AKI secondary to COVID‐19.