Open AccessEarly detection of SARS‐CoV‐2 and other infections in solid organ transplant recipients and household members using wearable devices
Author(s) -
Keating Brendan J.,
Mukhtar Eyas H.,
Elftmann Eric D.,
Eweje Feyisope R.,
Gao Hui,
Ibrahim Lina I.,
Kathawate Ranganath G.,
Lee Alexander C.,
Li Eric H.,
Moore Krista A.,
Nair Nikhil,
Chaluvadi Venkata,
Reason Janaiya,
Zai Francesca,
Honkala Alexander T.,
AlAli Amein K.,
Abdullah Alrubaish Fatima,
Ahmad AlMozaini Maha,
AlMuhanna Fahad A.,
AlRomaih Khaldoun,
Goldfarb Samuel B.,
Kellogg Ryan,
Kiryluk Krzysztof,
Kizilbash Sarah J.,
Kohut Taisa J.,
Kumar Juhi,
O'Connor Matthew J.,
Rand Elizabeth B.,
Redfield Robert R.,
Rolnik Benjamin,
Rossano Joseph,
Sanchez Pablo G.,
Alavi Arash,
Bahmani Amir,
Bogu Gireesh K.,
Brooks Andrew W.,
Metwally Ahmed A,
Mishra Tejas,
Marks Stephen D.,
Montgomery Robert A.,
Fishman Jay A.,
Amaral Sandra,
Jacobson Pamala A.,
Wang Meng,
Snyder Michael P.
Publication year - 2021
Publication title -
transplant international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.998
H-Index - 82
eISSN - 1432-2277
pISSN - 0934-0874
DOI - 10.1111/tri.13860
Subject(s) - medicine , transplantation , organ transplantation , family medicine , general surgery , gerontology
Summary The increasing global prevalence of SARS‐CoV‐2 and the resulting COVID‐19 disease pandemic pose significant concerns for clinical management of solid organ transplant recipients (SOTR). Wearable devices that can measure physiologic changes in biometrics including heart rate, heart rate variability, body temperature, respiratory, activity (such as steps taken per day) and sleep patterns, and blood oxygen saturation show utility for the early detection of infection before clinical presentation of symptoms. Recent algorithms developed using preliminary wearable datasets show that SARS‐CoV‐2 is detectable before clinical symptoms in >80% of adults. Early detection of SARS‐CoV‐2, influenza, and other pathogens in SOTR, and their household members, could facilitate early interventions such as self‐isolation and early clinical management of relevant infection(s). Ongoing studies testing the utility of wearable devices such as smartwatches for early detection of SARS‐CoV‐2 and other infections in the general population are reviewed here, along with the practical challenges to implementing these processes at scale in pediatric and adult SOTR, and their household members. The resources and logistics, including transplant‐specific analyses pipelines to account for confounders such as polypharmacy and comorbidities, required in studies of pediatric and adult SOTR for the robust early detection of SARS‐CoV‐2, and other infections are also reviewed.