Open AccessFunctional status‐based risk–benefit analyses of high‐ KDPI kidney transplant versus dialysis
Author(s) -
Bui Kevin,
Kilambi Vikram,
Mehrotra Sanjay
Publication year - 2019
Publication title -
transplant international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.998
H-Index - 82
eISSN - 1432-2277
pISSN - 0934-0874
DOI - 10.1111/tri.13483
Subject(s) - medicine , dialysis , proportional hazards model , cohort , multivariate analysis , kidney transplant , nephrology , kidney , surgery , kidney transplantation
Summary Yearly, over half of deceased‐donor kidneys with kidney donor profile index ( KDPI ) > 85 were discarded, yet they could improve survival outcomes for dialysis patients. The potential risk of high‐ KDPI kidney transplant ( KT ) depends on the patient's overall health summarized by functional status, which should be examined. The analyzed cohort consisted of adult deceased‐donor KT candidates on dialysis listed in 2005–2014. A multivariate Cox proportional hazards model was fitted with functional status, measured using Karnofsky Performance Score ( KPS ), and transplant status as time‐varying covariates. Derived from the Cox model, survival curves were analyzed to compare the survival outcomes between dialysis and transplant with different kidney qualities across three different KPS strata: 10–40, 50–70, and 80–100. With KDPI 0–99 KT , KPS 10–40 patients will survive ≥4.38 years median compared with 3.21 years median if they remained on dialysis. For KPS 50+ patients, the median survival years increase from 5.82 to 6.60 years on dialysis to ≥7.83 years after KDPI < 100 KT . The risk‐adjusted analyses suggested that patients are expected to benefit more from KDPI 81–99 KT than from remaining on dialysis.