Open AccessImmunological aspects of allogeneic pancreatic islet transplantation: a comparison between mouse and human
Author(s) -
Montanari Elisa,
GonelleGispert Carmen,
Seebach Jörg D.,
Knoll Michael F.,
Bottino Rita,
Bühler Leo H.
Publication year - 2019
Publication title -
transplant international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.998
H-Index - 82
eISSN - 1432-2277
pISSN - 0934-0874
DOI - 10.1111/tri.13445
Subject(s) - islet , allotransplantation , medicine , transplantation , diabetes mellitus , type 1 diabetes , islet cell transplantation , immunology , pancreatic islets , bioinformatics , endocrinology , biology
Summary Pancreatic islet allotransplantation is a treatment for patients with severe forms of type 1 diabetes. As long‐term graft function and survival are not yet optimal, additional studies are warranted in order to continue improving transplant outcomes. The mechanisms of islet graft loss and tolerance induction are often studied in murine diabetes models. Despite numerous islet transplantation studies successfully performed over recent years, translation from experimental mouse models to human clinical application remains elusive. This review aims at critically discussing the strengths and limitations of current mouse models of diabetes and experimental islet transplantation. In particular, we will analyze the causes leading to diabetes and compare the immunological mechanisms responsible for rejection between mouse and human. A better understanding of the experimental mouse models should facilitate translation to human clinical application.