Open AccessRenal volume assessed by magnetic resonance imaging volumetry correlates with renal function in living kidney donors pre‐ and postdonation: a retrospective cohort study
Author(s) -
Lange Daniel,
Helck Andreas,
Rominger Axel,
Crispin Alexander,
Meiser Bruno,
Werner Jens,
Fischereder Michael,
Stangl Manfred,
Habicht Antje
Publication year - 2018
Publication title -
transplant international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.998
H-Index - 82
eISSN - 1432-2277
pISSN - 0934-0874
DOI - 10.1111/tri.13150
Subject(s) - medicine , renal function , urology , kidney , magnetic resonance imaging , kidney donation , kidney disease , creatinine , scintigraphy , nephrectomy , retrospective cohort study , kidney transplantation , radiology
Summary Renal function of potential living kidney donors is routinely assessed with scintigraphy. Kidney anatomy is evaluated by imaging techniques such as magnetic resonance imaging ( MRI ). We evaluated if a MRI ‐based renal volumetry is a good predictor of kidney function pre‐ and postdonation. We retrospectively analyzed the renal volume ( RV ) in a MRI of 100 living kidney donors. RV was correlated with the tubular excretion rate ( TER ) of MAG 3‐scintigraphy, a measured creatinine clearance (CrCl), and the estimated glomerular filtration rate ( eGFR ) by Cockcroft‐Gault ( CG ), CKD ‐ EPI , and modification of diet in renal disease ( MDRD ) formula pre‐ and postdonation during a follow‐up of 3 years. RV correlated significantly with the TER (total: r = 0.6735, P < 0.0001). Correlation between RV and renal function was the highest for eGFR by CG ( r = 0.5595, P < 0.0001), in comparison with CrCl, MDRD ‐ GFR , and CKD ‐ EPI ‐ GFR predonation. RV significantly correlated with CG ‐ GFR postdonation and predicted CG ‐ GFR until 3 years after donation. MRI renal volumetry might be an alternative technique for the evaluation of split renal function and prediction of renal function postdonation in living kidney donors.