Open AccessRecall features and allorecognition in innate immunity
Author(s) -
Uehara Hirofumi,
Minami Koichiro,
Quante Markus,
Nian Yeqi,
Heinbokel Timm,
Azuma Haruhito,
Khal Abdala El,
Tullius Stefan G.
Publication year - 2018
Publication title -
transplant international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.998
H-Index - 82
eISSN - 1432-2277
pISSN - 0934-0874
DOI - 10.1111/tri.13073
Subject(s) - innate immune system , alloimmunity , acquired immune system , pattern recognition receptor , immunology , immunity , intrinsic immunity , biology , allorecognition , immune system , major histocompatibility complex
Summary Alloimmunity traditionally distinguishes short‐lived, rapid and nonspecific innate immune responses from adaptive immune responses that are characterized by a highly specific response initiated in a delayed fashion. Key players of innate immunity such as natural killer ( NK ) cells and macrophages present the first‐line defence of immunity. The concept of unspecific responses in innate immunity has recently been challenged. The discovery of pattern recognition receptors ( PRR s) has demonstrated that innate immune cells respond in a semi‐specific fashion through the recognition of pathogen‐associated molecular patterns ( PAMP s) representing conserved molecular structures shared by large groups of microorganisms. Although immunological memory has generally been considered as exclusive to adaptive immunity, recent studies have demonstrated that innate immune cells have the potential to acquire memory. Here, we discuss allospecific features of innate immunity and their relevance in transplantation.