Open AccessDonor predictors of allograft utilization for pediatric heart transplantation
Author(s) -
Khan Asma M.,
Green Robert S.,
Lytrivi Irene D.,
Sahulee Raj
Publication year - 2016
Publication title -
transplant international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.998
H-Index - 82
eISSN - 1432-2277
pISSN - 0934-0874
DOI - 10.1111/tri.12835
Subject(s) - medicine , transplantation , inotrope , logistic regression , ejection fraction , heart transplantation , surgery , cardiology , heart failure
Summary Pediatric heart transplantations are limited by the supply of donor allografts. We sought to determine the cardiac allograft utilization rate for pediatric donors and identify donor factors that predict graft use for transplantation. The United Network for Organ Sharing deceased donor database was queried from April 30, 2006, to March 31, 2014. Donor risk factors that might affect graft use for cardiac transplantation were evaluated. The pediatric cardiac graft utilization rate was calculated, and logistic regression modeling was performed to determine the relationship of risk factors with graft use for transplantation. During the study period, 6682 eligible cardiac donors <18 years of age were identified, and 3758 (56.2%) grafts were utilized for transplantation. Grafts from male donors ( OR 1.181) were significantly associated with graft utilization. Graft donor age >1 year ( OR 0.363), non‐O blood type ( OR 0.586), CDC ‘high‐risk’ donor status ( OR 0.676), use of inotropes ( OR 0.718), use of >2 inotropes ( OR 0.328), and donor left ventricular ejection fraction <50% ( OR 0.045) were significantly associated with graft nonutilization. The pediatric cardiac allograft utilization rate and risk factors for graft use for transplantation have been identified. Additional studies will be needed to assess the donor–recipient relationship on pediatric transplant outcomes.