Open AccessLiver transplantation for nonalcoholic steatohepatitis in young patients
Author(s) -
Alkhouri Naim,
Hanouneh Ibrahim A.,
Zein Nizar N.,
Lopez Rocio,
Kelly Dympna,
Eghtesad Bijan,
Fung John J.
Publication year - 2016
Publication title -
transplant international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.998
H-Index - 82
eISSN - 1432-2277
pISSN - 0934-0874
DOI - 10.1111/tri.12694
Subject(s) - medicine , liver transplantation , nonalcoholic steatohepatitis , cirrhosis , nonalcoholic fatty liver disease , steatohepatitis , young adult , gastroenterology , primary biliary cirrhosis , liver disease , fatty liver , transplantation , surgery , pediatrics , disease
Summary Nonalcoholic steatohepatitis (NASH) is the hepatic manifestation of obesity and insulin resistance. The aim of this study was to determine the frequency of NASH as an indication for liver transplantation (LT) in children and young adults and to characterize patient and graft survival. The study included all children and young adult patients (up to the age of 40 years) who underwent LT in the United States for NASH cirrhosis from the 1987 to 2012 United Network for Organ Sharing (UNOS) database. Kaplan–Meier analysis was used to assess patient and graft survival. A total of 330 patients were included, 68% were Caucasian, and the mean BMI was 33.6 ± 6.3. Age at time of LT ranged between 4 and 40 years (mean 33.9 ± 6.6 years). Fourteen subjects were <18 years of age at time of LT and 20 were between the ages of 18 and 25 years. Median follow‐up after 1st LT was 45.8 months [10.7, 97.3]. During this time, 30% of subjects ( n = 100) died and 11.5% ( n = 38) were retransplanted including 13 for NASH recurrence. In conclusion, NASH can progress to end‐stage liver disease requiring LT in childhood and early adulthood. A significant number of young patients transplanted for NASH cirrhosis required retransplantation.