Open AccessVirus‐specific T‐cell therapy in solid organ transplantation
Author(s) -
Roemhild Andy,
Reinke Petra
Publication year - 2016
Publication title -
transplant international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.998
H-Index - 82
eISSN - 1432-2277
pISSN - 0934-0874
DOI - 10.1111/tri.12659
Subject(s) - medicine , transplantation , hematopoietic cell , clinical trial , intensive care medicine , hematopoietic stem cell transplantation , cell therapy , antiviral therapy , stem cell , oncology , immunology , virus , haematopoiesis , biology , chronic hepatitis , genetics
Summary This article reviews the current state of T‐cell therapy as therapeutic option for virus‐associated diseases against the background of the most common viral complications and their standard treatment regimens after SOT . The available data of clinical T‐cell trials in SOT are summarized. References to the hematopoietic stem cell transplantation are made if applicable data in SOT are not available and their content was considered likewise valid for cell therapy in SOT . Moreover, aspects of different manufacturing approaches including beneficial product characteristics and the importance of GMP compliance are addressed.