Open AccessVisceral fat is better related to impaired glucose metabolism than body mass index after kidney transplantation
Author(s) -
Düring Marit Elizabeth,
Jenssen Trond,
Bollerslev Jens,
Åsberg Anders,
Godang Kristin,
Eide Ivar Anders,
Dahle Dag Olav,
Hartmann Anders
Publication year - 2015
Publication title -
transplant international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.998
H-Index - 82
eISSN - 1432-2277
pISSN - 0934-0874
DOI - 10.1111/tri.12606
Subject(s) - medicine , endocrinology , body mass index , impaired glucose tolerance , transplantation , obesity , carbohydrate metabolism , diabetes mellitus , type 2 diabetes , adipose tissue , impaired fasting glucose , kidney transplantation , kidney
Summary The role of visceral adipose tissue ( VAT ) in post‐transplant hyperglycaemia is not known. We evaluated 167 patients without diabetes 8‐10 weeks after kidney transplantation, performing oral glucose tolerance tests and measuring VAT content from dual‐energy X‐ray absorptiometry scans. Median VAT weight in normal glucose tolerance patients was 0.9 kg, impaired fasting glucose patients 1.0 kg, impaired glucose tolerance patients 1.3 kg and patients with post‐transplant diabetes ( PTDM ) 2.1 kg ( P = 0.004, indicating a difference between groups). Percentage VAT of total body fat was associated with fasting ( R 2 = 0.094, P < 0.001) and 2‐h glucose concentration ( R 2 = 0.062, P = 0.001), while BMI was only associated with 2‐h glucose concentration ( R 2 = 0.029, P = 0.028). An association between BMI and 2‐h glucose concentration was lost in adjusted models, as opposed to the associations between VAT as percentage of total body fat and glucose concentrations ( R 2 = 0.132, P < 0.001 and R 2 = 0.097, P = 0.001, respectively for fasting and 2‐h glucose concentration). In conclusion, VAT is more closely related to impaired glucose metabolism than BMI after kidney transplantation. The association with central obesity should encourage additional studies on lifestyle interventions to prevent PTDM .