Open AccessNutritional status of patients with alcoholic cirrhosis undergoing liver transplantation: time trends and impact on survival
Author(s) -
Singal Ashwani K.,
Kamath Patrick S.,
Francisco Ziller Nickie,
DiCecco Sara,
Shoreibah M.,
Kremers Walter,
Charlton Michael R.,
Heimbach Julie K.,
Watt Kymberly D.,
Shah Vijay H.
Publication year - 2013
Publication title -
transplant international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.998
H-Index - 82
eISSN - 1432-2277
pISSN - 0934-0874
DOI - 10.1111/tri.12123
Subject(s) - medicine , liver transplantation , alcoholic liver disease , cirrhosis , hepatocellular carcinoma , overweight , body mass index , transplantation , alcoholic hepatitis , cohort , malnutrition , liver disease , gastroenterology , hepatitis c , obesity , surgery
Summary Alcoholic cirrhotics evaluated for liver transplantation are frequently malnourished or obese. We analyzed alcoholic cirrhotics undergoing transplantation to examine time trends of nutrition/weight, transplant outcome, and effects of concomitant hepatitis C virus ( HCV ) and/or hepatocellular carcinoma ( HCC ). Nutrition and transplant outcomes were reviewed for alcoholic cirrhosis with/without HCV / HCC . Malnutrition was defined by subjective global assessment. Body mass index ( BMI ) classified obesity. A total of 261 patients receiving transplants were separated (1988–2000, 2001–2006, and 2007–2011) to generate similar size cohorts. Mean BMI for the whole cohort was 28 ± 6 with 68% classified as overweight/obese. Mean BMI did not vary among cohorts and was not affected by HCV / HCC . While prevalence of malnutrition did not vary among cohorts, it was lower in patients with HCV / HCC ( P < 0.01). One‐year graft/patient survival was 90% and not impacted by time period, HCV / HCC , or malnutrition after adjusting for demographics and model end‐stage liver disease ( MELD ). Alcoholic cirrhotics undergoing transplantation are malnourished yet frequently overweight/obese. Among patients selected for transplantation, 1‐year post‐transplant graft/patient survival is excellent, have not changed over time, and do not vary by nutrition/ BMI . Our findings support feasibility of liver transplantation for alcoholic cirrhotics with obesity and malnutrition.