Open AccessImpact of immunosenescence on transplant outcome
Author(s) -
Heinbokel Timm,
Hock Karin,
Liu Guangxiang,
Edtinger Karoline,
Elkhal Abdallah,
Tullius Stefan G.
Publication year - 2013
Publication title -
transplant international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.998
H-Index - 82
eISSN - 1432-2277
pISSN - 0934-0874
DOI - 10.1111/tri.12013
Subject(s) - immunosenescence , medicine , immunosuppression , transplantation , intensive care medicine , population , clinical trial , immunology , immune system , environmental health
Summary Aging affects all compartments of the immune response and has a major impact on transplant outcome and organ quality. Although clinical trials in the aging transplant population remain rare, our current understanding of immunosenescence provides a basis for an age‐adapted immunosuppression and organ allocation with the goal to optimize utilization and to improve outcomes in older recipients. From a more general perspective, understanding the mechanisms and consequences of immunosenescence will have a broad impact on immune therapies in and beyond transplantation.