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Passive transfer of SARS‐CoV ‐2 antibodies with platelet transfusions
Author(s) -
Ramirez Guillermo A.,
GautamGoyal Pranisha,
Shariatmadar Sherry,
Khatri Akshay,
McCannPineo Molly,
Rasul Rehana,
Karkenny Gabriel,
Chang Tylis,
Sfakianos Maria,
Cassiere Hugh,
Epstein Marcia
Publication year - 2022
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/trf.16841
Subject(s) - medicine , antibody , platelet , interquartile range , titer , immunology , platelet transfusion , mean platelet volume , apheresis , antibody titer , gastroenterology
Background Although over 5000 platelet transfusions occur daily in the United States, the presence of SARS‐CoV‐2 antibodies in platelet units is not commonly evaluated for. The effects of platelet transfusions with SARS‐CoV‐2 antibodies remain largely unknown. We evaluated single‐donor (apheresis) platelet units for SARS‐CoV‐2 antibodies and determined if platelet transfusions passively transferred antibodies to seronegative recipients. Study Design and Methods We conducted a retrospective analysis as part of a quality assurance initiative during February to March 2021 at a tertiary referral academic center in suburban New York. Platelet units and platelet recipients were evaluated for the presence of SARS‐CoV‐2 antibodies using the DiaSorin LIASON SARS‐CoV‐2 S1/S2 IgG assay. There were 47 platelet recipients eligible for study inclusion. The primary outcome was the presence of SARS‐CoV‐2 spike protein IgG antibodies in the recipient's blood after platelet transfusion. Results Twenty‐three patients received platelets with SARS‐CoV‐2 spike protein IgG antibodies; 13 recipients had detection of SARS‐COV‐2 antibodies (56.5%), and 10 recipients did not. The median antibody titer in the platelet units given to the group with passive antibodies detected was significantly higher compared to the median antibody titer in the platelet units given to the group without antibodies detected (median [interquartile range]: 306 AU/ml [132, 400] vs. 96.1 AU/ml [30.6, 186], p = .027). Conclusions Our study demonstrated a significant rate of passive transfer of SARS‐CoV‐2 spike protein IgG antibodies through platelet transfusions. Considering the volume of daily platelet transfusions, this is something all clinicians should be aware of.