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Exponential increase in neutralizing and spike specific antibodies following vaccination of COVID ‐19 convalescent plasma donors
Author(s) -
Vickers Molly A.,
Sariol Alan,
Leon Judith,
Ehlers Alexandra,
Locher Aaron V.,
Dubay Kerry A.,
Collins Laura,
Voss Dena,
Odle Abby E.,
Holida Myrl,
Merrill Anna E.,
Perlman Stanley,
Knudson C. Michael
Publication year - 2021
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/trf.16401
Subject(s) - convalescent plasma , covid-19 , antibody , medicine , titer , vaccination , virology , neutralizing antibody , immunology , neutralization , immunoassay , outbreak , infectious disease (medical specialty) , disease
Background With the recent approval of COVID‐19 vaccines, recovered COVID‐19 subjects who are vaccinated may be ideal candidates to donate COVID‐19 convalescent plasma (CCP). Case Series Eleven recovered COVID‐19 patients were screened to donate CCP. All had molecularly confirmed COVID‐19, and all but one were antibody positive by chemiluminescence immunoassay (DiaSorin) prior to vaccination. All were tested again for antibodies 11–21 days after they were vaccinated (Pfizer/Moderna). All showed dramatic increases (~50‐fold) in spike‐specific antibody levels and had at least a 20‐fold increase in the IC50 neutralizing antibody titer based on plaque reduction neutralization testing (PRNT). The spike‐specific antibody levels following vaccination were significantly higher than those seen in any non‐vaccinated COVID‐19 subjects tested to date at our facility. Conclusion Spike‐specific and neutralizing antibodies demonstrated dramatic increases following a single vaccination after COVID‐19 infection, which significantly exceeded values seen with COVID‐19 infection alone. Recovered COVID‐19 subjects who are vaccinated may make ideal candidates for CCP donation.