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Benefits of lower neonatal platelet transfusion thresholds
Author(s) -
Hasan Rida,
Saifee Nabiha H.
Publication year - 2021
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/trf.16386
Subject(s) - medicine , platelet , platelet transfusion , adverse effect , anesthesia , pediatrics , intensive care medicine
Key Ideas Degree of thrombocytopenia is not a predictor of bleeding risk in neonates, yet most platelet transfusions are given prophylactically in non‐bleeding premature infants. Recent data support a lower platelet transfusion threshold of 25 × 10 9 /L in non‐bleeding premature neonates and indicate that higher transfusion thresholds may be associated with harm including increased risk of death and bleeding. The mechanism of increased adverse events with higher platelet transfusion threshold is unknown, but considerations include adult platelets disrupting the neonatal hemostatic balance of hypoactive platelets in a hypercoagulable and fragile environment and having a pro‐inflammatory effect.