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Platelet transfusion refractoriness and anti‐HLA immunization
Author(s) -
Blandin Lucie,
Dougé Aurore,
Fayard Amandine,
Bay JacquesOlivier,
Berlie Guillaume,
Pereira Bruno,
Lemal Richard,
Rouzaire Paul
Publication year - 2021
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/trf.16358
Subject(s) - platelet , platelet transfusion , medicine , human leukocyte antigen , immunization , complication , immunology , antibody , blood transfusion , refractory (planetary science) , refractory period , antigen , biology , astrobiology
Platelet transfusion refractoriness (PTR), defined as an unsatisfactory post‐transfusion platelet count increment, is a common complication of patients receiving multiple transfusions. Different strategies are described in the management of PTR. In this work, we demonstrate the efficacy of the detection and identification of anti‐HLA antibodies in the recipient using a threshold of 3000 mean fluorescence intensity (MFI), and the seek of donors not expressing HLA antigens against which the patient is immunized.