A novel   RHD   allele caused by  c.739 G> C  mutation was identified in a  Chinese  individual | Zendy

Lyu Hongjuan | Zendy; Jiao Shuxian | Zendy; Ma Wenhui | Zendy; Hu Bin | Zendy

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A novel RHD allele caused by c.739 G> C mutation was identified in a Chinese individual

Author(s) -

Lyu Hongjuan,

Jiao Shuxian,

Ma Wenhui,

Hu Bin

Publication year - 2021

Publication title -

transfusion

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.045

H-Index - 132

eISSN - 1537-2995

pISSN - 0041-1132

DOI - 10.1111/trf.16133

Subject(s) - exon , allele , mutation , primer (cosmetics) , polymerase chain reaction , genetics , microbiology and biotechnology , biology , chinese population , population , gene , genotype , medicine , chemistry , organic chemistry , environmental health

The blood sample of a pregnant Chinese woman of the north Han population was confirmed as D variation by serologic method, and subsequent detection of RHD Exons 1 through 10 by the polymerase chain reaction–sequence‐specific primer test showed that all exons were present. To further clarify the molecular mechanism of this sample, we sequenced the RHD Exons 1 through 10 and found that it was a novel allele caused by c.739 G> C in Exon 5.

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