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A novel RHD allele caused by c.739 G> C mutation was identified in a Chinese individual
Author(s) -
Lyu Hongjuan,
Jiao Shuxian,
Ma Wenhui,
Hu Bin
Publication year - 2021
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/trf.16133
Subject(s) - exon , allele , mutation , primer (cosmetics) , polymerase chain reaction , genetics , microbiology and biotechnology , biology , chinese population , population , gene , genotype , medicine , chemistry , organic chemistry , environmental health
The blood sample of a pregnant Chinese woman of the north Han population was confirmed as D variation by serologic method, and subsequent detection of RHD Exons 1 through 10 by the polymerase chain reaction–sequence‐specific primer test showed that all exons were present. To further clarify the molecular mechanism of this sample, we sequenced the RHD Exons 1 through 10 and found that it was a novel allele caused by c.739 G> C in Exon 5.