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Assessment of a downsized potassium adsorption filter designed to transfuse neonates
Author(s) -
Ogasawara Kei,
Ohto Hitoshi,
Takano Nozomi,
Nollet Kenneth E.,
Go Hayato,
Sato Maki,
Momoi Nobuo,
Hosoya Mitsuaki
Publication year - 2020
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/trf.16010
Subject(s) - hyperkalemia , potassium , adsorption , filtration (mathematics) , dilution , chemistry , chromatography , medicine , mathematics , statistics , physics , organic chemistry , thermodynamics
Background During storage, the potassium level of red blood cell (RBC) components increases, especially after irradiation. Neonates are prone to hyperkalemia, for example, non‐oliguric hyperkalemia, so using potassium adsorption filters during transfusion may be helpful. To overcome dilution of RBC components caused by saline priming of existing potassium adsorption filters, a downsized potassium adsorption filter for neonates (PAF‐n, Kawasumi Laboratories Inc., Tokyo, Japan) was developed. Study Design and Methods To assess the performance of PAF‐n, its adsorption efficiency and RBC recovery rate were evaluated by testing pre‐filtration and serial post‐filtration (0‐30 mL, 30‐60 mL, 60‐90 mL, and 90‐120 mL) samples from 8 RBC components. Results The average potassium adsorption rate of the PAF‐n was 90.5% ± 0.78%, and never less than 89.0% in any of 8 RBC components. RBC recovery rates were 99.3% ± 1.12%. Conclusion The PAF‐n showed an effective potassium ability with negligible RBC dilution.