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Passenger lymphocyte thrombocytopenia due to human platelet antigen 3a antibodies: Case report and review of literature
Author(s) -
French Winnifred,
Hopkins Matthew,
Poles Anthony,
Mijovic Aleksandar
Publication year - 2020
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/trf.15905
Subject(s) - medicine , immunology , antibody , aplastic anemia , platelet , lymphocyte , platelet transfusion , antigen , bone marrow
We report a case of severe acute thrombocytopenia occurring within days after a cadaveric liver transplant, received from a female patient with aplastic anemia who died of intracranial bleeding. The donor, who was homozygous for the ITGA2B*002 (HPA‐3b) gene, had developed human platelet antigen (HPA)‐3a antibodies, whereas the recipient was homozygous for the ITGA2B*001 (HPA‐3a) gene. Thrombocytopenia responded to an infusion of immunoglobulin G. This is the first report of a passenger lymphocyte syndrome manifesting with thrombocytopenia due to anti‐HPA‐3a. We review the literature on thrombocytopenia in the setting of PLS and discuss the differential diagnosis.