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Chronological storage age and metabolic age of stored red blood cells: are they the same?
Author(s) -
D'Alessandro Angelo,
Zimring James C.,
Busch Michael
Publication year - 2019
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/trf.15248
Subject(s) - red blood cell , blood preservation , physiology , metabolism , biology , medicine , immunology , biochemistry
KEY IDEAS Red blood cell (RBC) storage in the blood bank is characterized by the progressive loss of metabolic regulation, a phenomenon that targets energy and antioxidant metabolism; While the progression of the storage lesion is inevitable, the rate at which this phenomenon occurs varies from donor to donor; Red blood cells from some donors at the end of storage are metabolically superior to RBCs from other donors at the beginning of storage, suggesting that the age of blood alone may not be a sufficiently accurate predictor of stored blood quality; and Animal studies and large‐scale omics screening in blood donors have helped identify mechanistic contributors to the metabolic heterogeneity of stored blood units.