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Influence of platelet preparation techniques on in vitro storage quality after psoralen‐based photochemical treatment using new processing sets for triple‐dose units
Author(s) -
Lotens Anaïs,
Valensart Nicolas,
Najdovski Tomé,
Acquart Sophie,
Cognasse Fabrice,
Rapaille André
Publication year - 2018
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/trf.14909
Subject(s) - psoralen , platelet , chemistry , apheresis , buffy coat , biomedical engineering , surgery , medicine , biochemistry , immunology , dna
BACKGROUND The INTERCEPT Blood System (IBS) for platelets (PLTs) uses a combination of psoralen and ultraviolet‐A light to inactivate pathogens that may contaminate PLT concentrates (PCs). However, no data are available on the quality of IBS‐treated PLTs from different apheresis and buffy‐coat PC preparation platforms using the new triple storage (TS) set. STUDY DESIGN AND METHODS The objective of this study was to evaluate the TS set on three different preparation platforms compared with the large‐volume (LV) set, as control. PLT in vitro metabolic and activation parameters were studied over 7 days. RESULTS Several statistical differences are observed between the two sets, particularly for pH, oxygen pressure (pO 2 ), carbonic gaz pressure (pCO 2 ), and bicarbonate. The three different preparation techniques influence PLT parameters, and the difference is statistically significant for all the studied parameters, except for pCO 2 . The TS set has the advantage of shorter compound adsorption device time, higher PLT recoveries, and less PLT activation. CONCLUSION Results from the measured metabolic parameters and PLT variables obtained from PCs treated by LV and TS sets indicated good PLT function preservation up to 7 days of storage. The in vitro assessment results demonstrated acceptable PLT function for transfusion.