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Storage after gamma irradiation affects in vivo oxygen delivery capacity of transfused red blood cells in preterm infants
Author(s) -
SaitoBenz Maria,
Murphy William G.,
Tzeng YuChieh,
Atkinson Greg,
Berry Mary J.
Publication year - 2018
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/trf.14764
Subject(s) - medicine , blood irradiation therapy , in vivo , irradiation , anemia , anesthesia , blood transfusion , oxygenation , oxygen saturation , oxygen , physiology , andrology , surgery , chemistry , biology , pathology , physics , alternative medicine , microbiology and biotechnology , organic chemistry , nuclear physics
BACKGROUND Gamma irradiation of red blood cells (RBCs) is well recognized to exacerbate storage lesion formation, but the effect of storage after irradiation on in vivo oxygen delivery capacity of transfused RBCs is currently not known. STUDY DESIGN AND METHODS In 24 preterm infants with anemia receiving nonurgent transfusion of irradiated RBCs, we examined cerebral regional tissue oxygenation (crSO 2 ) and time spent with peripheral arterial saturation (SpO 2 ) less than 88%. Physiologic data were obtained immediately before, immediately after, and 5 days after transfusion. RESULTS We observed linear negative moderate correlations between time since irradiation and the magnitude of change in crSO 2 (r = –0.60; 95% CI, –0.81 to –0.27; p = 0.0018) and time spent with SpO 2 of less than 88% (r = –0.42; 95% CI, –0.71 to 0.003; p = 0.04) immediately after transfusion. In infants (n = 9) who received fresher RBCs (irradiated <10 days before transfusion), there was a sustained increase in mean crSO 2 up to 5 days after transfusion (3.0%; 95% CI, 0.3% to 5.7%; p = 0.04). Conversely, in infants (n = 15) who received older RBCs (irradiated ≥10 days before transfusion), there were negligible changes in crSO 2 after transfusion at any time point. CONCLUSION Our findings indicate that storage after gamma irradiation may have a detrimental effect on the oxygen delivery capacity of RBCs given to anemic preterm infants.