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Synergistic effects of intravenous and intra‐articular tranexamic acid on reducing hemoglobin loss in revision total knee arthroplasty: a prospective, randomized, controlled study
Author(s) -
Yuan Xiangwei,
Wang Jiaxing,
Wang Qiaojie,
Zhang Xianlong
Publication year - 2018
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/trf.14477
Subject(s) - tranexamic acid , medicine , anesthesia , intra articular , surgery , saline , hemoglobin , randomized controlled trial , arthroplasty , total knee arthroplasty , tourniquet , blood loss , osteoarthritis , alternative medicine , pathology
BACKGROUND Tranexamic acid decreases blood loss in primary total knee arthroplasty, and no related prospective randomized clinical trials have been conducted to evaluate the effectiveness and safety of tranexamic acid in revision total knee arthroplasty. Thus, we conducted this work to evaluate the synergistic effects of intravenous plus intra‐articular tranexamic acid on reducing hemoglobin loss compared with intra‐articular tranexamic acid alone in revision total knee arthroplasty. STUDY DESIGN AND METHODS This prospective, controlled study randomized 96 patients undergoing revision total knee arthroplasty into two groups: an intravenous plus intra‐articular tranexamic acid group (48 patients who received 20 mg/kg intravenous tranexamic acid and 3.0 g intra‐articular tranexamic acid); and an intra‐articular tranexamic acid alone group (48 patients who received the same intravenous volume of normal saline and 3.0 g intra‐articular tranexamic acid). The primary outcome was hemoglobin loss. Secondary outcomes included the volume of drain output, the percentage of patients who received transfusions, the number of units transfused, and thromboembolic events. RESULTS The baseline data, preoperative hemoglobin, and tourniquet time were similar in both groups. There was significantly less hemoglobin loss in the intravenous plus intra‐articular tranexamic acid group compared with the intra‐articular tranexamic acid alone group (2.7 ± 0.6 g/dL and 3.7 ± 0.7 g/dL; p < 0.001). Compared with the intra‐articular tranexamic acid alone group, the intravenous plus intra‐articular tranexamic acid group also had significantly less drain output, fewer patients who received transfusions, and fewer units transfused (all p < 0.05). There were no significant differences in thromboembolic events in the two groups during the 3‐month follow‐up. CONCLUSION Compared with intra‐articular tranexamic acid alone, combined intravenous plus intra‐articular tranexamic acid significantly reduced hemoglobin loss and the need for transfusion without an apparent increase in thromboembolic events in patients who underwent revision total knee arthroplasty.